Health A-Z

Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by inflammation and damage to the liver, specifically inflammation and liver cell damage caused by a buildup of fat in the liver. NASH is considered a more severe form of nonalcoholic fatty liver disease (NAFLD). Here's an overview of the symptoms, diagnosis, and treatment options for NASH.

1. Fatigue: Fatigue and weakness are common symptoms of NASH.
2. Abdominal Discomfort: Some individuals may experience discomfort or pain in the upper right side of the abdomen, where the liver is located.
3. Weight Loss: Unintentional weight loss may occur in some individuals with advanced NASH.
4. Enlarged Liver: In some cases, the liver may become enlarged (hepatomegaly).
5. Fluid Buildup: Fluid accumulation in the abdomen (ascites) or legs (edema) may occur in advanced stages of NASH.
6. Jaundice: Yellowing of the skin and eyes (jaundice) may occur in severe cases of NASH, indicating liver dysfunction.

1. Lifestyle Modifications: Lifestyle changes are often the first line of treatment for NASH and may include:
   • Weight Loss: Losing weight through a combination of diet and exercise can help reduce fat accumulation in the liver and improve liver health.
   • Healthy Diet: Following a balanced, low-fat diet rich in fruits, vegetables, and whole grains can help improve liver function.
   • Regular Exercise: Engaging in regular physical activity can help reduce liver fat and improve overall health.
2. Medications: There are currently no medications specifically approved for the treatment of NASH, but certain medications may be used off-label to manage symptoms or reduce liver inflammation.
3. Management of Coexisting Conditions: Managing conditions such as diabetes, obesity, and high cholesterol is important for overall health and may help improve liver function in individuals with NASH.
4. Clinical Trials: Participation in clinical trials may be an option for individuals with NASH who are interested in experimental treatments or therapies under investigation.

1. Medical History and Physical Examination: A healthcare provider will conduct a thorough medical history and physical examination to assess symptoms and risk factors for liver disease.
2. Blood Tests: Blood tests may be performed to assess liver function and check for elevated levels of liver enzymes, which can indicate liver inflammation or damage.
3. Imaging Studies: Imaging tests such as ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) may be used to evaluate the liver and assess for signs of fatty liver disease and inflammation.
4. Liver Biopsy: A liver biopsy may be performed to confirm the diagnosis of NASH and assess the severity of liver damage. During a liver biopsy, a small sample of liver tissue is removed and examined under a microscope.