Health A-Z

Gilbert's syndrome is a common, harmless liver condition in which the liver doesn't properly process bilirubin, leading to mild elevations in bilirubin levels in the blood. Here's a breakdown of symptoms, treatment plans, and diagnosis/testing for Gilbert's syndrome.

1. Yellowing of the Skin (Jaundice): Mild jaundice may occur intermittently, causing a yellowish discoloration of the skin and whites of the eyes.
2. Fatigue: Some individuals with Gilbert's syndrome may experience fatigue, though it's often mild and intermittent.
3. Abdominal Discomfort: Rarely, individuals may experience mild abdominal discomfort or other gastrointestinal symptoms, such as bloating or nausea.

1. No Specific Treatment: In most cases, no specific treatment is required for Gilbert's syndrome, as it is a benign condition that does not cause significant health problems.
2. Lifestyle Modifications: Some individuals may find that certain lifestyle modifications, such as maintaining a healthy diet, staying hydrated, getting regular exercise, and avoiding excessive alcohol consumption, help alleviate symptoms and promote overall well-being.
3. Awareness of Triggers: Certain factors, such as fasting, stress, illness, and certain medications, can temporarily exacerbate jaundice in individuals with Gilbert's syndrome. Being aware of these triggers and taking appropriate precautions may help manage symptoms.

1. Blood Tests: Blood tests, specifically measuring bilirubin levels, are used to diagnose Gilbert's syndrome. Individuals with Gilbert's syndrome typically have mildly elevated unconjugated (indirect) bilirubin levels, while other liver function tests remain normal.
2. Medical History and Physical Examination: A medical history and physical examination can help rule out other liver conditions and identify characteristic features of Gilbert's syndrome, such as a history of mild jaundice.
3. Genetic Testing (Optional): In some cases, genetic testing may be performed to confirm the diagnosis of Gilbert's syndrome. Mutations in the UGT1A1 gene are associated with this condition.