Health A-Z

It seems you're referring to Z-E Syndrome, which stands for Zollinger-Ellison syndrome. It's a rare condition where tumors (gastrinomas) form in the pancreas or duodenum, causing excessive production of gastrin, a hormone that stimulates acid secretion in the stomach. Here's some information on its symptoms, treatment, and diagnosis.

1. Abdominal Pain: Often severe and recurrent.
2. Heartburn: Frequent and severe.
3. Nausea and vomiting: Due to increased acid levels.
4. Diarrhea: Sometimes chronic and severe.
5. Weight Loss: Can be significant due to malabsorption.
6. Bleeding: Occurs in some cases due to ulceration.

1. Proton Pump Inhibitors (PPIs): These drugs suppress gastric acid secretion, providing relief from symptoms and allowing ulcers to heal.
2. Surgery: Removal of tumors from the pancreas or duodenum can often cure the syndrome.
3. Chemotherapy: Used in cases where tumors have spread beyond the point of surgical removal.
4. Lifestyle Changes: Avoiding alcohol, caffeine, and spicy foods can help manage symptoms.
5. Regular Monitoring: Gastrin levels and imaging studies may be periodically monitored to check for tumor recurrence.

1. Blood Tests: Measure gastrin levels. Elevated levels may indicate Zollinger-Ellison syndrome.
2. Endoscopy: Allows direct visualization of the stomach and duodenum to identify ulcers or tumors.
3. Imaging: CT scan, MRI, or ultrasound can locate tumors.
4. Secretin Stimulation Test: Measures gastrin levels before and after injecting secretin, a hormone that normally inhibits gastrin release. In Z-E syndrome, gastrin levels remain high despite secretin injection.
5. Endoscopic Ultrasound: Provides detailed images of the pancreas and surrounding structures to detect tumors.